Stefan F Lichtenthaler Selected Research

Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)

12/2021	Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation.
1/2021	Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.
7/2010	Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway.

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Stefan F Lichtenthaler Research Topics

Disease

71	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 03/2003
8	Neoplasms (Cancer) 01/2024 - 02/2013
7	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2023 - 01/2019
5	Amyloid Plaque 01/2022 - 05/2010
4	Inflammation (Inflammations) 04/2024 - 03/2006
4	Frontotemporal Dementia (Semantic Dementia) 11/2023 - 03/2013
4	Cognitive Dysfunction 06/2023 - 06/2006
4	Amyloidosis 12/2022 - 01/2016
3	Infections 01/2022 - 04/2013
3	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 12/2021 - 07/2010
3	Multiple Sclerosis 11/2020 - 01/2015
2	Glioblastoma (Glioblastoma Multiforme) 10/2023 - 10/2022
2	CADASIL 01/2022 - 01/2018
2	Vesicular Stomatitis 10/2021 - 12/2018
2	Mental Disorders (Mental Disorder) 01/2020 - 01/2020
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/2015 - 01/2015
2	Autoimmune Diseases (Autoimmune Disease) 06/2015 - 01/2015
2	Neuroblastoma 07/2013 - 11/2011
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 04/2013 - 07/2008
1	Pituitary Neoplasms (Pituitary Adenoma) 01/2024
1	Proteostasis Deficiencies 01/2023
1	Chronic Disease (Chronic Diseases) 10/2022
1	COVID-19 01/2022
1	Autism Spectrum Disorder 01/2022
1	Synucleinopathies 01/2022
1	Familial Cerebral Amyloid Angiopathy 01/2022
1	Cerebral Small Vessel Diseases 01/2022
1	Demyelinating Diseases (Demyelinating Disease) 10/2021
1	Acute Disseminated Encephalomyelitis (Postinfectious Encephalomyelitis) 11/2020
1	Psychotic Disorders (Schizoaffective Disorder) 11/2020
1	Central Nervous System Diseases (CNS Diseases) 10/2020
1	Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy 01/2018
1	Lymphoma (Lymphomas) 01/2018
1	Tauopathies 01/2017
1	Arthritis (Polyarthritis) 01/2017
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2017
1	Brain Diseases (Brain Disorder) 01/2016
1	Gliosis 01/2016
1	Schizophrenia (Dementia Praecox) 01/2016
1	Neuroinflammatory Diseases 01/2016
1	Disease Progression 01/2015
1	Neoplasm Metastasis (Metastasis) 12/2014

Drug/Important Bio-Agent (IBA)

56	Proteins (Proteins, Gene)FDA Link 04/2024 - 03/2003
49	Amyloid (Amyloid Fibrils)IBA 11/2023 - 12/2003
25	Peptide Hydrolases (Proteases)FDA Link 01/2024 - 01/2006
24	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2024 - 05/2004
20	Amyloid beta-PeptidesIBA 01/2020 - 03/2003
20	Peptides (Polypeptides)IBA 01/2020 - 05/2004
12	EnzymesIBA 07/2023 - 12/2004
8	Metalloproteases (Metalloproteinases)IBA 01/2022 - 01/2011
6	ProteomeIBA 06/2023 - 01/2018
6	Aspartic Acid ProteasesIBA 01/2019 - 12/2003
5	Biomarkers (Surrogate Marker)IBA 06/2023 - 06/2015
4	Membrane Proteins (Integral Membrane Proteins)IBA 01/2024 - 03/2006
4	LipidsIBA 06/2023 - 01/2021
4	PrionsIBA 01/2023 - 04/2013
4	LigandsIBA 10/2022 - 01/2015
3	Protein AggregatesIBA 01/2023 - 04/2013
3	CytokinesIBA 10/2022 - 02/2013
3	Glycoproteins (Glycoprotein)IBA 10/2021 - 01/2013
2	GranulinsIBA 06/2023 - 01/2023
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2022 - 08/2006
2	CholesterolIBA 12/2021 - 07/2010
2	RNA (Ribonucleic Acid)IBA 01/2021 - 01/2017
2	DisintegrinsIBA 01/2020 - 01/2016
2	Immunoglobulin G (IgG)IBA 06/2015 - 01/2015
2	Transcription Factors (Transcription Factor)IBA 04/2011 - 06/2006
1	ProgranulinsIBA 11/2023
1	sortilinIBA 11/2023
1	Antiviral Agents (Antivirals)IBA 01/2023
1	Interleukin-6 (Interleukin 6)IBA 01/2023
1	VaccinesIBA 12/2022
1	Chimeric Antigen ReceptorsIBA 10/2022
1	Cell Surface ReceptorsIBA 10/2022
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2021
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 10/2021
1	2-5A-dependent ribonuclease (RNase L)IBA 01/2021
1	AutoantibodiesIBA 11/2020
1	AntigensIBA 01/2019
1	Hemagglutinins (Hemagglutinin)IBA 12/2018
1	Neuraminidase (Sialidase)IBA 12/2018
1	annonacinIBA 01/2017
1	NeurotoxinsIBA 01/2017
1	Tissue Inhibitor of Metalloproteinase-3IBA 01/2017
1	Phosphotransferases (Kinase)IBA 01/2017
1	Tiopronin (Thiola)FDA Link 02/2016
1	Presenilin-1IBA 01/2016
1	SynaptophysinIBA 01/2016
1	tau Proteins (tau Protein)IBA 01/2016
1	Sirtuin 2IBA 01/2016
1	PresenilinsIBA 01/2016
1	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 06/2015
1	TACI receptor-IgG Fc fragment fusion proteinIBA 01/2015
1	Catechin (Z 7300)IBA 01/2015
1	nardilysinIBA 01/2014
1	4- amino- 5- chloro- 2,3- dihydrobenzofuran- 7- carboxylic acid (3- hydroxy- 1- (3- methoxypropyl)piperidin- 4ylmethyl)amideIBA 07/2013
1	prucaloprideIBA 07/2013
1	5-HT4 Serotonin ReceptorsIBA 07/2013

Therapy/Procedure

1	Immunotherapy 12/2018
1	Therapeutics 01/2017